Synthesis of 3-((trifluoromethyl)thio)indoles via trifluoromethylthiolation of 2-alkynyl azidoarenes with AgSCF<inf>3</inf>

• Main Authors: Jongkonporn Phetcharawetch, Nolan M. Betterley, Vichai Reutrakul, Darunee Soorukram, Pawaret Leowanawat, Chutima Kuhakarn
• 其他作者: Mahidol University
• 格式: Article
• 出版: 2022
• 主題: Biochemistry, Genetics and Molecular Biology; Chemistry; Environmental Science
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/76013

Direct and effective trifluoromethylthiolation of 2-alkynyl azidoarenes with silver(I) trifluoromethanethiolate (AgSCF3) has been developed for the construction of 3-((trifluoromethyl)thio)indoles. The trifluoromethylthiolation protocol is compatible with a broad substrate scope, providing a variety...