Synthesis of gem-difluoromethylenated spiro-γ-butyrolactones by employing PhSCF<inf>2</inf>Si(CH<inf>3</inf>)<inf>3</inf>as a gem-difluoromethylenating agent

• Main Authors: Adisak Chatupheeraphat, Darunee Soorukram, Chutima Kuhakarn, Patoomratana Tuchinda, Vichai Reutrakul, Chaveng Pakawatchai, Saowanit Saithong, Manat Pohmakotr
• 其他作者: Mahidol University
• 格式: Article
• 出版: 2018
• 主題: Chemistry
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/31510

PhSCF2TMS was utilized as a useful gem-difluoromethylene building block for the synthesis of gem-difluoromethylenated spiro-γ-butyrolactones. The radical cyclization of γ-alkenyl- γ-gem-difluoro(phenylsulfanyl)methyl-γ-butyrolactones provided gem-difluoromethylenated spiro-γ-butyrolactones. PhSCF2TM...