Cyclization of o-Alkynylisocyanobenzenes with 1,3-Dicarbonyl Compounds
A facile and convenient reaction of o-alkynylisocyanobenzenes with various active-methylene compounds, including 1,3-diesters, 1,3-diketones, β-keto esters, and β-keto amides, under Brønsted basic conditions, has been developed. Diethyl malonate reacted smoothly with a collection of o-alkynylisocyan...
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| Main Authors: | , , , , , , , , |
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| 其他作者: | |
| 格式: | Article |
| 出版: |
2022
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| 主題: | |
| 在線閱讀: | https://repository.li.mahidol.ac.th/handle/123456789/73721 |
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| 機構: | Mahidol University |
| 總結: | A facile and convenient reaction of o-alkynylisocyanobenzenes with various active-methylene compounds, including 1,3-diesters, 1,3-diketones, β-keto esters, and β-keto amides, under Brønsted basic conditions, has been developed. Diethyl malonate reacted smoothly with a collection of o-alkynylisocyanobenzenes to provide the corresponding 2-quinolin-2-yl malonates in excellent yields. Acetylacetone gave a mixture of quinolin-4-yl and quinolin-2-yl derivatives. Acetoacetate esters and acetoacetyl amide derivative initially gave 2-quinolin-2-yl adducts that underwent partial deacetylation under the reaction conditions. |
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