Asymmetric Synthesis of Trifluoromethylated ent-Fragransin C <inf>1</inf>

• المؤلفون الرئيسيون: Sasirome Racochote, Manat Pohmakotr, Chutima Kuhakarn, Pawaret Leowanawat, Vichai Reutrakul, Darunee Soorukram
• مؤلفون آخرون: Mahidol University
• التنسيق: مقال
• منشور في: 2020
• الموضوعات: Chemistry
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/50573

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Asymmetric synthesis of trifluoromethylated derivative of ent-fragransin C 1 was reported. The installation of contiguous stereochemistries across the tetrahydrofuran scaffold was achieved through stereocontrolled conjugate addition, aldol reaction, and a protection-free intramolecular C-O bond formation (furan ring formation) via chemoselective generation of the benzylic carbocation.