Synthesis of Difluoromethyl Ketones from Weinreb Amides, and Tandem Addition/Cyclization of o-Alkynylaryl Weinreb Amides

Synthesis of Difluoromethyl Ketones from Weinreb Amides, and Tandem Addition/Cyclization of o-Alkynylaryl Weinreb Amides

© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim [Difluoro(phenylsulfanyl)methyl]trimethylsilane (PhSCF2SiMe3) underwent a fluoride-induced nucleophilic addition to the carbonyl group of Weinreb amides to provide the corresponding difluoro(phenylsulfanyl)methyl ketones. These were converted i...

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Bibliographic Details
Main Authors: Jongkonporn Phetcharawetch, Nolan M. Betterley, Darunee Soorukram, Manat Pohmakotr, Vichai Reutrakul, Chutima Kuhakarn
Other Authors: Mahidol University
Format: Article
Published: 2018
Subjects:
Chemistry
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/42163
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https://repository.li.mahidol.ac.th/handle/123456789/42163

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