Synthesis of Difluoromethyl Ketones from Weinreb Amides, and Tandem Addition/Cyclization of o-Alkynylaryl Weinreb Amides

• المؤلفون الرئيسيون: Jongkonporn Phetcharawetch, Nolan M. Betterley, Darunee Soorukram, Manat Pohmakotr, Vichai Reutrakul, Chutima Kuhakarn
• مؤلفون آخرون: Mahidol University
• التنسيق: مقال
• منشور في: 2018
• الموضوعات: Chemistry
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/42163

© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim [Difluoro(phenylsulfanyl)methyl]trimethylsilane (PhSCF2SiMe3) underwent a fluoride-induced nucleophilic addition to the carbonyl group of Weinreb amides to provide the corresponding difluoro(phenylsulfanyl)methyl ketones. These were converted i...