Synthesis of aryl α-keto esters via the rearrangement of aryl cyanohydrin carbonate esters

• Main Authors: Nopporn Thasana, Vilailak Prachyawarakorn, Sopchok Tontoolarug, Somsak Ruchirawat
• 其他作者: Chulabhorn Research Institute
• 格式: Article
• 出版: 2018
• 主題: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/20770

A facile synthesis of aryl α-keto esters is reported involving the rearrangement of aryl cyanohydrin carbonate esters induced by the α-carbanion to the nitrile group generated by LDA. However, under similar conditions, an o-benzyloxycyanohydrin carbonate ester rearranged via a domino reaction leadin...