Synthesis of aryl α-keto esters via the rearrangement of aryl cyanohydrin carbonate esters

• المؤلفون الرئيسيون: Nopporn Thasana, Vilailak Prachyawarakorn, Sopchok Tontoolarug, Somsak Ruchirawat
• مؤلفون آخرون: Chulabhorn Research Institute
• التنسيق: مقال
• منشور في: 2018
• الموضوعات: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/20770

A facile synthesis of aryl α-keto esters is reported involving the rearrangement of aryl cyanohydrin carbonate esters induced by the α-carbanion to the nitrile group generated by LDA. However, under similar conditions, an o-benzyloxycyanohydrin carbonate ester rearranged via a domino reaction leadin...