IBX/n-Bu<inf>4</inf>NBr/CH<inf>2</inf>Cl<inf>2</inf>-H<inf>2</inf>O: A new mild system for selective oxidation of secondary alcohols

IBX/n-Bu<inf>4</inf>NBr/CH<inf>2</inf>Cl<inf>2</inf>-H<inf>2</inf>O: A new mild system for selective oxidation of secondary alcohols

A new alternative system for the chemoselective oxidation of secondary hydroxyl group to ketone with IBX/n-Bu4NBr in CH2Cl2-H2O has been developed. Under the reaction conditions, the secondary hydroxyl group was highly chemoselectively oxidized to the corresponding ketone, in moderate to good yields...

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Main Authors: Chutima Kuhakarn, Krisada Kittigowittana, Manat Pohmakotr, Vichai Reutrakul
Other Authors: Mahidol University
Format: Article
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology
Chemistry
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/16295
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Institution: Mahidol University
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spelling th-mahidol.162952018-06-21T15:33:44Z IBX/n-Bu<inf>4</inf>NBr/CH<inf>2</inf>Cl<inf>2</inf>-H<inf>2</inf>O: A new mild system for selective oxidation of secondary alcohols Chutima Kuhakarn Krisada Kittigowittana Manat Pohmakotr Vichai Reutrakul Mahidol University Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics A new alternative system for the chemoselective oxidation of secondary hydroxyl group to ketone with IBX/n-Bu4NBr in CH2Cl2-H2O has been developed. Under the reaction conditions, the secondary hydroxyl group was highly chemoselectively oxidized to the corresponding ketone, in moderate to good yields at rt, in the presence of primary hydroxyl group within the same molecule. © 2005 Elsevier Ltd. All rights reserved. 2018-06-21T08:08:14Z 2018-06-21T08:08:14Z 2005-09-19 Article Tetrahedron. Vol.61, No.38 (2005), 8995-9000 10.1016/j.tet.2005.07.051 00404020 2-s2.0-23944511343 https://repository.li.mahidol.ac.th/handle/123456789/16295 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=23944511343&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Biochemistry, Genetics and Molecular Biology
Chemistry
Pharmacology, Toxicology and Pharmaceutics
spellingShingle Biochemistry, Genetics and Molecular Biology
Chemistry
Pharmacology, Toxicology and Pharmaceutics
Chutima Kuhakarn
Krisada Kittigowittana
Manat Pohmakotr
Vichai Reutrakul
IBX/n-Bu<inf>4</inf>NBr/CH<inf>2</inf>Cl<inf>2</inf>-H<inf>2</inf>O: A new mild system for selective oxidation of secondary alcohols
description A new alternative system for the chemoselective oxidation of secondary hydroxyl group to ketone with IBX/n-Bu4NBr in CH2Cl2-H2O has been developed. Under the reaction conditions, the secondary hydroxyl group was highly chemoselectively oxidized to the corresponding ketone, in moderate to good yields at rt, in the presence of primary hydroxyl group within the same molecule. © 2005 Elsevier Ltd. All rights reserved.
author2 Mahidol University
author_facet Mahidol University
Chutima Kuhakarn
Krisada Kittigowittana
Manat Pohmakotr
Vichai Reutrakul
format Article
author Chutima Kuhakarn
Krisada Kittigowittana
Manat Pohmakotr
Vichai Reutrakul
author_sort Chutima Kuhakarn
title IBX/n-Bu<inf>4</inf>NBr/CH<inf>2</inf>Cl<inf>2</inf>-H<inf>2</inf>O: A new mild system for selective oxidation of secondary alcohols
title_short IBX/n-Bu<inf>4</inf>NBr/CH<inf>2</inf>Cl<inf>2</inf>-H<inf>2</inf>O: A new mild system for selective oxidation of secondary alcohols
title_full IBX/n-Bu<inf>4</inf>NBr/CH<inf>2</inf>Cl<inf>2</inf>-H<inf>2</inf>O: A new mild system for selective oxidation of secondary alcohols
title_fullStr IBX/n-Bu<inf>4</inf>NBr/CH<inf>2</inf>Cl<inf>2</inf>-H<inf>2</inf>O: A new mild system for selective oxidation of secondary alcohols
title_full_unstemmed IBX/n-Bu<inf>4</inf>NBr/CH<inf>2</inf>Cl<inf>2</inf>-H<inf>2</inf>O: A new mild system for selective oxidation of secondary alcohols
title_sort ibx/n-bu<inf>4</inf>nbr/ch<inf>2</inf>cl<inf>2</inf>-h<inf>2</inf>o: a new mild system for selective oxidation of secondary alcohols
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/16295
_version_ 1763489963440078848

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