A small molecule CFTR potentiator restores ATP-dependent channel gating to the cystic fibrosis mutant G551D-CFTR
Background and Purpose: Cystic fibrosis transmembrane conductance regulator (CFTR) potentiators are small molecules developed to treat the genetic disease cystic fibrosis (CF). They interact directly with CFTR Cl− channels at the plasma membrane to enhance channel gating. Here, we investigate the ac...
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| 格式: | Article |
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2023
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| 在線閱讀: | https://repository.li.mahidol.ac.th/handle/123456789/86875 |
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| 機構: | Mahidol University |