PLGA nanoparticles containing α-fetoprotein siRNA induce apoptosis and enhance the cytotoxic effects of doxorubicin in human liver cancer cell line

• المؤلفون الرئيسيون: Theeraphong Pho-iam, Primana Punnakitikashem, Chayapol Somboonyosdech, Sirinapa Sripinitchai, Patarabutr Masaratana, Vorapan Sirivatanauksorn, Yongyut Sirivatanauksorn, Chamaiphorn Wongwan, Kytai T. Nguyen, Chatchawan Srisawat
• مؤلفون آخرون: Siriraj Hospital
• التنسيق: مقال
• منشور في: 2022
• الموضوعات: Biochemistry, Genetics and Molecular Biology
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/76180

Hepatocellular carcinoma (HCC) is one of the most common cancers and is a leading cause of death. Delivery of therapeutic molecules, e.g., siRNA, to HCC cells could potentially be an alternative treatment for HCC. In this study, the siRNA targeting α-fetoprotein (AFP) mRNA was found to specifically...