PLGA nanoparticles containing α-fetoprotein siRNA induce apoptosis and enhance the cytotoxic effects of doxorubicin in human liver cancer cell line

• Main Authors: Theeraphong Pho-iam, Primana Punnakitikashem, Chayapol Somboonyosdech, Sirinapa Sripinitchai, Patarabutr Masaratana, Vorapan Sirivatanauksorn, Yongyut Sirivatanauksorn, Chamaiphorn Wongwan, Kytai T. Nguyen, Chatchawan Srisawat
• 其他作者: Siriraj Hospital
• 格式: Article
• 出版: 2022
• 主題: Biochemistry, Genetics and Molecular Biology
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/76180

Hepatocellular carcinoma (HCC) is one of the most common cancers and is a leading cause of death. Delivery of therapeutic molecules, e.g., siRNA, to HCC cells could potentially be an alternative treatment for HCC. In this study, the siRNA targeting α-fetoprotein (AFP) mRNA was found to specifically...