Curcumin and metformin synergistically modulate peripheral and central immune mechanisms of pain

• Main Authors: Peththa Wadu Dasuni Wasana, Hasriadi, Chawanphat Muangnoi, Opa Vajragupta, Pranee Rojsitthisak, Pornchai Rojsitthisak, Pasarapa Towiwat
• Other Authors: Metallurgy and Materials Research Institute Chulalongkorn University
• Format: Article
• Published: 2022
• Subjects: Multidisciplinary
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/75389
• Institution: Mahidol University

Metformin is a well-tolerated antidiabetic drug and has recently been repurposed for numerous diseases, including pain. However, a higher dose of metformin is required for effective analgesia, which can potentiate its dose-dependent gastrointestinal side effects. Curcumin is a natural polyphenol and...