Physicochemical investigation of a novel curcumin diethyl γ-aminobutyrate, a carbamate ester prodrug of curcumin with enhanced anti-neuroinflammatory activity

• Main Authors: Ponsiree Jithavech, Piyapan Suwattananuruk, Hasriadi, Chawanphat Muangnoi, Worathat Thitikornpong, Pasarapa Towiwat, Opa Vajragupta, Pornchai Rojsitthisak
• Other Authors: Chulalongkorn University
• Format: Article
• Published: 2022
• Subjects: Multidisciplinary
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/75481

Curcumin is a polyphenol compound that alleviates several neuroinflammation-related diseases including Alzheimer's disease, Parkinson's disease, multiple sclerosis, epilepsy and cerebral injury. However, the therapeutic efficacy of curcumin is limited by its poor physicochemical properties...