Novel triazole-tetrahydroisoquinoline hybrids as human aromatase inhibitors

• المؤلفون الرئيسيون: Chanamon Chamduang, Ratchanok Pingaew, Veda Prachayasittikul, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul
• مؤلفون آخرون: Chulabhorn Research Institute
• التنسيق: مقال
• منشور في: 2020
• الموضوعات: Biochemistry, Genetics and Molecular Biology; Chemistry
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/50014

© 2019 Elsevier Inc. Novel thirteen triazole-tetrahydroisoquinoline derivatives (2a-m) were synthesized and evaluated for their aromatase inhibitory activities. Seven triazoles showed significant aromatase inhibitory activity (IC50 = 0.07–1.9 μM). Interestingly, the analog bearing naphthalenyloxymet...