Novel triazole-tetrahydroisoquinoline hybrids as human aromatase inhibitors

Novel triazole-tetrahydroisoquinoline hybrids as human aromatase inhibitors

© 2019 Elsevier Inc. Novel thirteen triazole-tetrahydroisoquinoline derivatives (2a-m) were synthesized and evaluated for their aromatase inhibitory activities. Seven triazoles showed significant aromatase inhibitory activity (IC50 = 0.07–1.9 μM). Interestingly, the analog bearing naphthalenyloxymet...

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Bibliographic Details
Main Authors: Chanamon Chamduang, Ratchanok Pingaew, Veda Prachayasittikul, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul
Other Authors: Chulabhorn Research Institute
Format: Article
Published: 2020
Subjects:
Biochemistry, Genetics and Molecular Biology
Chemistry
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/50014
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/50014

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