Synthesis of 3-substituted quinolin-2(1H)-ones via the cyclization of o-alkynylisocyanobenzenes

• Main Authors: Ailada Charoenpol, Jatuporn Meesin, Onnicha Khaikate, Vichai Reutrakul, Manat Pohmakotr, Pawaret Leowanawat, Darunee Soorukram, Chutima Kuhakarn
• Other Authors: Mahidol University
• Format: Article
• Published: 2019
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/45273

© The Royal Society of Chemistry. A facile synthesis of various functionalized 3-substituted quinolin-2(1H)-ones through Ag(i) nitrate-catalyzed cyclization of o-alkynylisocyanobenzenes is described. The reaction allows rapid and convenient access to 3-substituted quinolin-2(1H)-one scaffolds in mod...