Downregulation of LAT1 expression suppresses cholangiocarcinoma cell invasion and migration

• Main Authors: Keatdamrong Janpipatkul, Kanoknetr Suksen, Suparerk Borwornpinyo, Natee Jearawiriyapaisarn, Suradej Hongeng, Pawinee Piyachaturawat, Arthit Chairoungdua
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/33338

Currently, there is no effective treatment for cholangiocarcinoma (CCA), which is the most prevalent in the northeastern part of Thailand. A new molecular target for the treatment of CCA is, therefore, urgently needed. Although L-type amino acid transporter 1 (LAT1) is highly expressed in CCA cells,...