Asymmetric synthesis of pentenomycin I, epipentenomycin I, and their analogs

The synthetic utility of the intramolecular acylation of α-sulfinyl carbanions as an efficient and general synthetic approach for the preparation of (-)-pentenomycin I (1) and (-)-epipentenomycin I (5) and their enantiomers (ent-1 and ent-5), starting from chiral (2S,5S,6S)-ester 6 and ent-6, respec...

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Main Authors:	Manat Pohmakotr, Supakeat Kambutong, Patoomratana Tuchinda, Chutima Kuhakarn
Other Authors:	Mahidol University
Format:	Article
Published:	2018
Subjects:	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://repository.li.mahidol.ac.th/handle/123456789/18904
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Institution:	Mahidol University

id	th-mahidol.18904
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spelling	th-mahidol.189042018-07-12T09:50:42Z Asymmetric synthesis of pentenomycin I, epipentenomycin I, and their analogs Manat Pohmakotr Supakeat Kambutong Patoomratana Tuchinda Chutima Kuhakarn Mahidol University Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics The synthetic utility of the intramolecular acylation of α-sulfinyl carbanions as an efficient and general synthetic approach for the preparation of (-)-pentenomycin I (1) and (-)-epipentenomycin I (5) and their enantiomers (ent-1 and ent-5), starting from chiral (2S,5S,6S)-ester 6 and ent-6, respectively, has been demonstrated. Easy accesses to pentenomycin analogs have also been demonstrated through the Pummerer, Suzuki-Miyaura, and Sonogashira reactions. © 2008 Elsevier Ltd. All rights reserved. 2018-07-12T02:18:16Z 2018-07-12T02:18:16Z 2008-06-30 Article Tetrahedron. Vol.64, No.27 (2008), 6315-6323 10.1016/j.tet.2008.04.089 00404020 2-s2.0-44349090861 https://repository.li.mahidol.ac.th/handle/123456789/18904 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=44349090861&origin=inward
institution	Mahidol University
building	Mahidol University Library
continent	Asia
country	Thailand Thailand
content_provider	Mahidol University Library
collection	Mahidol University Institutional Repository
topic	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics Manat Pohmakotr Supakeat Kambutong Patoomratana Tuchinda Chutima Kuhakarn Asymmetric synthesis of pentenomycin I, epipentenomycin I, and their analogs
description	The synthetic utility of the intramolecular acylation of α-sulfinyl carbanions as an efficient and general synthetic approach for the preparation of (-)-pentenomycin I (1) and (-)-epipentenomycin I (5) and their enantiomers (ent-1 and ent-5), starting from chiral (2S,5S,6S)-ester 6 and ent-6, respectively, has been demonstrated. Easy accesses to pentenomycin analogs have also been demonstrated through the Pummerer, Suzuki-Miyaura, and Sonogashira reactions. © 2008 Elsevier Ltd. All rights reserved.
author2	Mahidol University
author_facet	Mahidol University Manat Pohmakotr Supakeat Kambutong Patoomratana Tuchinda Chutima Kuhakarn
format	Article
author	Manat Pohmakotr Supakeat Kambutong Patoomratana Tuchinda Chutima Kuhakarn
author_sort	Manat Pohmakotr
title	Asymmetric synthesis of pentenomycin I, epipentenomycin I, and their analogs
title_short	Asymmetric synthesis of pentenomycin I, epipentenomycin I, and their analogs
title_full	Asymmetric synthesis of pentenomycin I, epipentenomycin I, and their analogs
title_fullStr	Asymmetric synthesis of pentenomycin I, epipentenomycin I, and their analogs
title_full_unstemmed	Asymmetric synthesis of pentenomycin I, epipentenomycin I, and their analogs
title_sort	asymmetric synthesis of pentenomycin i, epipentenomycin i, and their analogs
publishDate	2018
url	https://repository.li.mahidol.ac.th/handle/123456789/18904
_version_	1763489031748845568

Asymmetric synthesis of pentenomycin I, epipentenomycin I, and their analogs

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