γ-Regioselectivity of lithiated 2-buten-4-olide towards aromatic aldehydes: A simple synthesis of γ-arylidenebutenolides

• Main Authors: Manat Pohmakotr, Patoomratana Tuchinda, Pornchai Premkaisorn, Vichai Reutrakul
• 其他作者: Mahidol University
• 格式: Article
• 出版: 2018
• 主題: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/18292

Lithiated 2-buten-4-olide was found to react with aromatic aldehydes regioselectively at γ-position to provide 4-(1-aryl-1-hydroxymethyl)-2- buten-4-olides which could be readily converted into the corresponding (Z)- γ-arylidenebutenolides.