Proteomic profiling of cholangiocarcinoma cell line treated with pomiferin from Derris malaccensis

• Main Authors: Jisnuson Svasti, Chantragan Srisomsap, Pantipa Subhasitanont, Siriporn Keeratichamroen, Daranee Chokchaichamnankit, Lukana Ngiwsara, Nitirat Chimnoi, Somchai Pisutjaroenpong, Supanna Techasakul, Shui Tein Chen
• Other Authors: Chulabhorn Research Institute
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/16276

Pomiferin, a prenylated isoflavonoid from Derris malaccensis with strong anti-fungal and anti-oxidant activities, showed cytotoxic activity towards human cholangiocarcinoma cells (HuCCA-1), with IC50 of 0.9 μg/mL. Pomiferin caused apoptosis, detectable by DNA fragmentation. Two-dimensional PAGE show...