Proteomic profiling of cholangiocarcinoma cell line treated with pomiferin from Derris malaccensis

• Main Authors: Jisnuson Svasti, Chantragan Srisomsap, Pantipa Subhasitanont, Siriporn Keeratichamroen, Daranee Chokchaichamnankit, Lukana Ngiwsara, Nitirat Chimnoi, Somchai Pisutjaroenpong, Supanna Techasakul, Shui Tein Chen
• 其他作者: Chulabhorn Research Institute
• 格式: Article
• 出版: 2018
• 主題: Biochemistry, Genetics and Molecular Biology
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/16276
• 機構: Mahidol University

Pomiferin, a prenylated isoflavonoid from Derris malaccensis with strong anti-fungal and anti-oxidant activities, showed cytotoxic activity towards human cholangiocarcinoma cells (HuCCA-1), with IC50 of 0.9 μg/mL. Pomiferin caused apoptosis, detectable by DNA fragmentation. Two-dimensional PAGE show...