Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers

• المؤلفون الرئيسيون: Supannee Phothongkam, Sirirat Chancharunee, Angkana Saovapakhiran, Uthai Wichai, Manat Pohmakotr
• مؤلفون آخرون: Chiang Mai University
• التنسيق: مقال
• منشور في: 2018
• الموضوعات: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/13546
• المؤسسة: Mahidol University

In this research, N-(2-aminoethyl)glycine-linked C-10 non-acetal deoxoartemisinin dimers were synthesized by using solution phase peptide synthesis approach. In addition, chemical modification of the C-10 non-acetal deoxoartemisinin monomers and dimers by adding a lysine unit to the N-terminus has b...