Overcoming multidrug resistance in human lung cancer with novel benzo[a]quinolizin-4-ones

• Main Authors: Yodsoi Kanintronkul, Rattana Worayuthakarn, Nopporn Thasana, Pakorn Winayanuwattikun, Kovit Pattanapanyasat, Rudee Surarit, Somsak Ruchirawat, Jisnuson Svasti
• 其他作者: Chulabhorn Research Institute
• 格式: Article
• 出版: 2018
• 主題: Biochemistry, Genetics and Molecular Biology; Medicine
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/11585
• 機構: Mahidol University

Aim: To investigate the ability of synthetic benzo[a]quinolizin-4-one derivatives to reverse multidrug resistance (MDR) in lung cancer cells. Materials and Methods: A cell line with MDR, A5 49RT-eto, was established by exposure to 1.5 μM etoposide. Cytotoxic activity was assayed by the 3-(4,5-dimeth...