Overcoming multidrug resistance in human lung cancer with novel benzo[a]quinolizin-4-ones

• المؤلفون الرئيسيون: Yodsoi Kanintronkul, Rattana Worayuthakarn, Nopporn Thasana, Pakorn Winayanuwattikun, Kovit Pattanapanyasat, Rudee Surarit, Somsak Ruchirawat, Jisnuson Svasti
• مؤلفون آخرون: Chulabhorn Research Institute
• التنسيق: مقال
• منشور في: 2018
• الموضوعات: Biochemistry, Genetics and Molecular Biology; Medicine
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/11585
• المؤسسة: Mahidol University

Aim: To investigate the ability of synthetic benzo[a]quinolizin-4-one derivatives to reverse multidrug resistance (MDR) in lung cancer cells. Materials and Methods: A cell line with MDR, A5 49RT-eto, was established by exposure to 1.5 μM etoposide. Cytotoxic activity was assayed by the 3-(4,5-dimeth...