Impaired insulin signaling affects renal organic anion transporter 3 (Oat3) function in streptozotocin-induced diabetic rats

• Main Authors: Lungkaphin A., Arjinajarn P., Pongchaidecha A., Srimaroeng C., Chatsudthipong L., Chatsudthipong V.
• 格式: Article
• 語言: English
• 出版: Public Library of Science 2014
• 在線閱讀: http://www.scopus.com/inward/record.url?eid=2-s2.0-84900441583&partnerID=40&md5=695c88ddfeca7d274715dde76270c909; http://cmuir.cmu.ac.th/handle/6653943832/4815

Organic anion transporter 3 (Oat3) is a major renal Oats expressed in the basolateral membrane of renal proximal tubule cells. We have recently reported decreases in renal Oat3 function and expression in diabetic rats and these changes were recovered after insulin treatment for four weeks. However,...