Impaired insulin signaling affects renal organic anion transporter 3 (Oat3) function in streptozotocin-induced diabetic rats

• المؤلفون الرئيسيون: Lungkaphin A., Arjinajarn P., Pongchaidecha A., Srimaroeng C., Chatsudthipong L., Chatsudthipong V.
• التنسيق: مقال
• اللغة: English
• منشور في: Public Library of Science 2014
• الوصول للمادة أونلاين: http://www.scopus.com/inward/record.url?eid=2-s2.0-84900441583&partnerID=40&md5=695c88ddfeca7d274715dde76270c909; http://cmuir.cmu.ac.th/handle/6653943832/4815

Organic anion transporter 3 (Oat3) is a major renal Oats expressed in the basolateral membrane of renal proximal tubule cells. We have recently reported decreases in renal Oat3 function and expression in diabetic rats and these changes were recovered after insulin treatment for four weeks. However,...