Butelase 1 : the fastest known ligase for protein cyclization and ligation

• المؤلف الرئيسي: Chen, Shu Bee
• مؤلفون آخرون: Jimmy Pingkwan Tam @ James P Tam
• التنسيق: Final Year Project
• اللغة: English
• منشور في: 2014
• الموضوعات: DRNTU::Science
• الوصول للمادة أونلاين: http://hdl.handle.net/10356/61748

Peptide cyclization confers increased conformational stability and rigidity against metabolic and thermal denaturation. Encouraged by potential usage of cyclic peptides in the therapeutic applications, methods of protein cyclization and ligation have been developed such as native chemical ligation,...