Synthesis and skin permeation study of lidocaine organic salts

• المؤلفون الرئيسيون: Opa Vajragupta, Supreeya La-Ong
• مؤلفون آخرون: Mahidol University
• التنسيق: مقال
• منشور في: 2018
• الموضوعات: Chemistry; Medicine; Pharmacology, Toxicology and Pharmaceutics
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/9551

Four organic quarternary ammonium salts of lidocaine, lidocaine adipate, lidocaine maleate, lidocaine malonate and lidocaine tosylate were prepared in this study. These compounds were regarded as prodrugs of lidocaine and were expected to enhance skin permeability by ion-pair approach. In vitro perm...