New lignans from anogeissus acuminata with HIV-1 reverse transcriptase inhibitory activity

• Main Authors: Agnes M. Rimando, John M. Pezzuto, Norman R. Farnsworth, Thawatchai Santisuk, Vichai Reutrakul, Kazuko Kawanishi
• Other Authors: University of Illinois at Chicago
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/9509

Anolignan A [1] and anolignan B [3] are new dibenzylbutadiene lignans isolated from Anogeissus acuminata. Compounds 1 and 3 were identified as the active HIV-1 reverse transcriptase (RT) inhibitory constituents of this plant obtained by bioassay-guided fractionation. Compound 3, which was very weak...