Validation of a chloroquine-induced cell death mechanism for clinical use against malaria.

• المؤلفون الرئيسيون: Ch’ng, J-H, Lee, Y-Q, Gun, SY, Chia, W-N, Chang, Z-W, Wong, L-K, Batty, KT, Russell, B, Nosten, F, Renia, L, Tan, KS-W
• التنسيق: مقال
• اللغة: English
• منشور في: 2015
• الموضوعات: Antimalarials; Chloroquine; Malaria; Plasmodium; Open Access article
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/796
• المؤسسة: Mahidol University

An alternative antimalarial pathway of an 'outdated' drug, chloroquine (CQ), may facilitate its return to the shrinking list of effective antimalarials. Conventionally, CQ is believed to interfere with hemozoin formation at nanomolar concentrations, but resistant parasites are able to ef...