Chloroquine is grossly under dosed in young children with malaria: implications for drug resistance.

• المؤلفون الرئيسيون: Ursing, Johan, Eksborg, Staffan, Rombo, Lars, Bergqvist, Yngve, Blessborn, Daniel, Rodrigues, Amabelia, Kofoed, Poul-Erik
• التنسيق: مقال
• اللغة: English
• منشور في: 2014
• الموضوعات: Antimalarials; Chloroquine; Drug resistance; Malaria; Open Access article
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/753

BACKGROUND: Plasmodium falciparum malaria is treated with 25 mg/kg of chloroquine (CQ) irrespective of age. Theoretically, CQ should be dosed according to body surface area (BSA). The effect of dosing CQ according to BSA has not been determined but doubling the dose per kg doubled the efficacy of CQ...