GRP78/BiP determines senescence evasion cell fate after cisplatin-based chemotherapy

• Main Authors: Zin Zin Ei, Kanuengnit Choochuay, Alisa Tubsuwan, Decha Pinkaew, Maneewan Suksomtip, Chanida Vinayanuwattikun, Pithi Chanvorachote, Preedakorn Chunhacha
• 其他作者: University of Washington School of Medicine
• 格式: Article
• 出版: 2022
• 主題: Multidisciplinary
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/79195

Cisplatin (CDDP) induces senescence characterized by senescence-associated secretory phenotypes (SASP) and the unfolded protein response (UPR). In this study, we investigated the proteins related to the UPR during the senescence cell fate. Strikingly, we found that one of the critical ER-resident pr...