Development of a Physiologically Based Pharmacokinetic Model of Mitragynine, Psychoactive Alkaloid in Kratom (Mitragyna Speciosa Korth.), In Rats and Humans

• المؤلفون الرئيسيون: Kimheang Ya, Janthima Methaneethorn, Quoc Ba Tran, Satariya Trakulsrichai, Winai Wananukul, Manupat Lohitnavy
• مؤلفون آخرون: Duy Tan University
• التنسيق: مقال
• منشور في: 2022
• الموضوعات: Medicine; Psychology
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/78878

Mitragynine is a major psychoactive alkaloid in leaves of kratom (Mitragyna speciosa Korth.). To understand its disposition in organs, this study aimed to develop a physiologically based pharmacokinetic (PBPK) model that predicts mitragynine concentrations in plasma and organ of interests in rats an...