Development of a Physiologically Based Pharmacokinetic Model of Mitragynine, Psychoactive Alkaloid in Kratom (Mitragyna Speciosa Korth.), In Rats and Humans

• Main Authors: Kimheang Ya, Janthima Methaneethorn, Quoc Ba Tran, Satariya Trakulsrichai, Winai Wananukul, Manupat Lohitnavy
• Other Authors: Duy Tan University
• Format: Article
• Published: 2022
• Subjects: Medicine; Psychology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/78878
• Institution: Mahidol University

Mitragynine is a major psychoactive alkaloid in leaves of kratom (Mitragyna speciosa Korth.). To understand its disposition in organs, this study aimed to develop a physiologically based pharmacokinetic (PBPK) model that predicts mitragynine concentrations in plasma and organ of interests in rats an...