A simple and efficient preparation of bis(indolyl)methanes catalyzed by HCl/silica gel under solvent-free conditions
A rapid, simple and efficient method for the synthesis of bis(indolyl)methanes (BIMs) via the electrophilic substitution reaction of indoles with benzaldehydes promoted by hydrochloric acid supported on silica gel was developed. The advantages of the present method entail short reaction times, high...
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th-mahidol.766242022-08-04T15:25:25Z A simple and efficient preparation of bis(indolyl)methanes catalyzed by HCl/silica gel under solvent-free conditions Praewpan Katrun Karnjana Atthawilai Chutima Kuhakarn Khon Kaen University Mahidol University Chemistry A rapid, simple and efficient method for the synthesis of bis(indolyl)methanes (BIMs) via the electrophilic substitution reaction of indoles with benzaldehydes promoted by hydrochloric acid supported on silica gel was developed. The advantages of the present method entail short reaction times, high yields, ease of experimental method and product isolation, benign reaction conditions and low cost. 2022-08-04T08:25:25Z 2022-08-04T08:25:25Z 2021-01-01 Article Arkivoc. Vol.2021, (2021) 10.24820/ark.5550190.p011.502 15517012 15517004 2-s2.0-85106530468 https://repository.li.mahidol.ac.th/handle/123456789/76624 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85106530468&origin=inward |
| institution |
Mahidol University |
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Mahidol University Library |
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Asia |
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Thailand Thailand |
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Mahidol University Institutional Repository |
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Chemistry |
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Chemistry Praewpan Katrun Karnjana Atthawilai Chutima Kuhakarn A simple and efficient preparation of bis(indolyl)methanes catalyzed by HCl/silica gel under solvent-free conditions |
| description |
A rapid, simple and efficient method for the synthesis of bis(indolyl)methanes (BIMs) via the electrophilic substitution reaction of indoles with benzaldehydes promoted by hydrochloric acid supported on silica gel was developed. The advantages of the present method entail short reaction times, high yields, ease of experimental method and product isolation, benign reaction conditions and low cost. |
| author2 |
Khon Kaen University |
| author_facet |
Khon Kaen University Praewpan Katrun Karnjana Atthawilai Chutima Kuhakarn |
| format |
Article |
| author |
Praewpan Katrun Karnjana Atthawilai Chutima Kuhakarn |
| author_sort |
Praewpan Katrun |
| title |
A simple and efficient preparation of bis(indolyl)methanes catalyzed by HCl/silica gel under solvent-free conditions |
| title_short |
A simple and efficient preparation of bis(indolyl)methanes catalyzed by HCl/silica gel under solvent-free conditions |
| title_full |
A simple and efficient preparation of bis(indolyl)methanes catalyzed by HCl/silica gel under solvent-free conditions |
| title_fullStr |
A simple and efficient preparation of bis(indolyl)methanes catalyzed by HCl/silica gel under solvent-free conditions |
| title_full_unstemmed |
A simple and efficient preparation of bis(indolyl)methanes catalyzed by HCl/silica gel under solvent-free conditions |
| title_sort |
simple and efficient preparation of bis(indolyl)methanes catalyzed by hcl/silica gel under solvent-free conditions |
| publishDate |
2022 |
| url |
https://repository.li.mahidol.ac.th/handle/123456789/76624 |
| _version_ |
1763487511905042432 |