Self-assembled thermoresponsive nanogel from grafted hyaluronic acid as a biocompatible delivery platform for curcumin with enhanced drug loading and biological activities

• Main Authors: Jittima Amie Luckanagul, Pahweenvaj Ratnatilaka Na Bhuket, Chawanphat Muangnoi, Pranee Rojsitthisak, Qian Wang, Pornchai Rojsitthisak
• 其他作者: Metallurgy and Materials Research Institute Chulalongkorn University
• 格式: Article
• 出版: 2022
• 主題: Chemistry; Materials Science
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/76623
• 機構: Mahidol University

A hyaluronic acid-grafted poly(N-isopropylacrylamide) (HA-pNIPAM) was synthesized as a polymeric nanogel platform for encapsulation and delivery of hydrophobic bioactive compounds using curcumin as a model drug. As demonstrated by transmission electron microscopy and dynamic light scattering techniq...