Antispasmodic effect of asperidine b, a pyrrolidine derivative, through inhibition of l-type ca²⁺ channel in rat ileal smooth muscle

• Main Authors: Acharaporn Duangjai, Vatcharin Rukachaisirikul, Yaowapa Sukpondma, Chutima Srimaroeng, Chatchai Muanprasat
• Other Authors: University of Phayao
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/76042

Antispasmodic agents are used for modulating gastrointestinal motility. Several compounds isolated from terrestrial plants have antispasmodic properties. This study aimed to explore the inhibitory effect of the pyrrolidine derivative, asperidine B, isolated from the soil-derived fungus Aspergillus s...