Synthesis, physicochemical properties, and protective effects of a novel water-soluble tetrahydrocurcumin-diglutaric acid prodrug on ethanol-induced toxicity in HepG2 cells

• Main Authors: Nattapong Jongjitphisut, Rianthong Phumsuay, Worathat Thitikornpong, Paitoon Rashatasakhon, Chawanphat Muangnoi, Opa Vajragupta, Pornchai Rojsitthisak
• Other Authors: Chulalongkorn University
• Format: Article
• Published: 2022
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/75233

Purpose: Tetrahydrocurcumin (THC) is a major reductive metabolite of curcumin that exhibits potent antioxidant effects; however, its pharmacological activities are limited by its poor water solubility. To overcome this, tetrahydrocurcumin-diglutaric acid (TDG), a novel water-soluble ester prodrug of...