Pinostrobin inhibits renal CFTR-mediated Cl⁻ secretion and retards cyst growth in cell-derived cyst and polycystic kidney disease rats

• المؤلفون الرئيسيون: Kanlayanee Tonum, Napason Chabang, Somsak Fongsupa, Suphat Chantawarin, Chutima Jiarpinitnun, Patoomrattana Tuchinda, Sunhapas Soodvilai
• مؤلفون آخرون: Mahidol University
• التنسيق: مقال
• منشور في: 2022
• الموضوعات: Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/73377

Cystic fibrosis transmembrane conductance regulator (CFTR) plays crucial role in renal cyst expansion via increase in fluid accumulation. Inhibition of CFTR has been proposed to retard cyst development and enlargement in polycystic kidney disease (PKD). Pinostrobin, a bioactive natural flavonoid, po...