SYNTHESIS OF ACETAMIDOSULFONAMIDE DERIVATIVES WITH ANTIOXIDATIVE AND QSAR STUDIES

• Main Authors: Apilak Worachartcheewan, Somchai Pisutjaroenpong, Ratchanok Pingaew, Supaluk Prachayasittikul, Suphakit Siriwong, Somsak Ruchirawat, Virapong Prachayasittikul
• Other Authors: Chulabhorn Research Institute
• Format: Article
• Published: 2022
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/73110

A series of sixteen acetamidosulfonamide derivatives (1-16) have been synthesized and investigated for their antioxidant (radical scavenging and superoxide dismutase (SOD)) and antimicrobial activities. Most compounds exhibited antioxidant activities in which compound 15 displayed the most potent ra...