Inhibition of topoisomerase IIα and induction of DNA damage in cholangiocarcinoma cells by altholactone and its halogenated benzoate derivatives

• Main Authors: Sarunya Kitdumrongthum, Somrudee Reabroi, Kanoknetr Suksen, Patoomratana Tuchinda, Bamroong Munyoo, Panupong Mahalapbutr, Thanyada Rungrotmongkol, Puey Ounjai, Arthit Chairoungdua
• 其他作者: Chulalongkorn University
• 格式: Article
• 出版: 2020
• 主題: Pharmacology, Toxicology and Pharmaceutics
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/54701
• 機構: Mahidol University

© 2020 The Author(s) Topoisomerase IIα enzyme (Topo IIα) plays a critical function in DNA replication process and is considered to be a promising target of anti-cancer drugs. In the present study, we reported that the altholactone derivatives modified by adding a halogenated benzoate group showed gr...