Oxidative Difluoromethylation of Tetrahydroisoquinolines Using TMSCF<inf>2</inf>SPh: Synthesis of Fluorinated Pyrrolo[2,1-a]isoquinolines and Benzo[a]quinolizidines

• المؤلفون الرئيسيون: Teerachai Punirun, Darunee Soorukram, Chutima Kuhakarn, Vichai Reutrakul, Manat Pohmakotr
• مؤلفون آخرون: Mahidol University
• التنسيق: مقال
• منشور في: 2019
• الموضوعات: Chemistry
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/45512

© 2017 American Chemical Society. An efficient C1-difluoromethylation of tetrahydroisoquinolenes was achieved using TMSCF2SPh as a difluoromethylating agent and 2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate (TEMPO+BF4-) as an oxidant. The process provides an access to a variety of C1...