Halogenated trimethoprim derivatives as multidrug-resistant Staphylococcus aureus therapeutics

• المؤلفون الرئيسيون: Napon Nilchan, Wanida Phetsang, Taechin Nowwarat, Soraya Chaturongakul, Chutima Jiarpinitnun
• مؤلفون آخرون: Mahidol University
• التنسيق: مقال
• منشور في: 2019
• الموضوعات: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/45028

© 2018 Elsevier Ltd Incorporation of halogen atoms to drug molecule has been shown to improve its properties such as enhanced in membrane permeability and increased hydrophobic interactions to its target. To investigate the effect of halogen substitutions on the antibacterial activity of trimethopri...