The Threshold of protection from liver-stage malaria relies on a fine balance between the number of infected hepatocytes and effector cd8⁺t cells present in the liver

• المؤلفون الرئيسيون: Alexandra J. Spencer, Rhea J. Longley, Anita Gola, Marta Ulaszewska, Teresa Lambe, Adrian V.S. Hill
• مؤلفون آخرون: University of Oxford
• التنسيق: مقال
• منشور في: 2018
• الموضوعات: Immunology and Microbiology
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/42790

Since the demonstration of sterile protection afforded by injection of irradiated sporozoites, CD8+T cells have been shown to play a significant role in protection from liver-stage malaria. This is, however, dependent on the presence of an extremely high number of circulating effector cells, thought...