G-CSF maintains controlled neutrophil mobilization during acute inflammation by negatively regulating CXCR2 signaling

• Main Authors: Besnik Bajrami, Haiyan Zhu, Hyun Jeong Kwak, Subhanjan Mondal, Qingming Hou, Guangfeng Geng, Kutay Karatepe, Yu C. Zhang, César Nombela-Arrieta, Shin Young Park, Fabien Loison, Jiro Sakai, Yuanfu Xu, Leslie E. Silberstein, Hongbo R. Luo
• Other Authors: Harvard Medical School
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/40895
• Institution: Mahidol University

© 2016 Bajrami et al. Cytokine-induced neutrophil mobilization from the bone marrow to circulation is a critical event in acute inflammation, but how it is accurately controlled remains poorly understood. In this study, we report that CXCR2 ligands are responsible for rapid neutrophil mobilization d...