Formal synthesis of (+)-3-epi-eupomatilone-6 and the 3,5-bis-epimer

• Main Authors: Sariya Yodwaree, Darunee Soorukram, Chutima Kuhakarn, Patoomratana Tuchinda, Vichai Reutrakul, Manat Pohmakotr
• 其他作者: Mahidol University
• 格式: Article
• 出版: 2018
• 主題: Biochemistry, Genetics and Molecular Biology; Chemistry
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/33224

The formal synthesis of (+)-3-epi-eupomatilone-6 (1) and the 3,5-bis-epimer (2) has been accomplished. The key synthetic strategy involved the stereoselective construction of (3R,4S,5R)- and (3R,4S,5S)-trisubstituted γ-butyrolactones 3 and 4 from (2R,3R)-2,3-dimethyl-4-pentenoic acid derivative 7, w...