A genome wide association study of Plasmodium falciparum susceptibility to 22 antimalarial drugs in Kenya

• Main Authors: Jason P. Wendler, John Okombo, Roberto Amato, Olivo Miotto, Steven M. Kiara, Leah Mwai, Lewa Pole, John O'Brien, Magnus Manske, Dan Alcock, Eleanor Drury, Mandy Sanders, Samuel O. Oyola, Cinzia Malangone, Dushyanth Jyothi, Alistair Miles, Kirk A. Rockett, Bronwyn L. MacInnis, Kevin Marsh, Philip Bejon, Alexis Nzila, Dominic P. Kwiatkowski
• 其他作者: University of Oxford
• 格式: Article
• 出版: 2018
• 主題: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/33021
• 機構: Mahidol University

Background: Drug resistance remains a chief concern for malaria control. In order to determine the genetic markers of drug resistant parasites, we tested the genome-wide associations (GWA) of sequence-based genotypes from 35 Kenyan P. falciparum parasites with the activities of 22 antimalarial drugs...