Involvement of the P2X<inf>7</inf>purinergic receptor and c-Jun N-terminal and extracellular signal-regulated kinases in cyclooxygenase-2 and prostaglandin E<inf>2</inf>induction by LL-37

Involvement of the P2X<inf>7</inf>purinergic receptor and c-Jun N-terminal and extracellular signal-regulated kinases in cyclooxygenase-2 and prostaglandin E<inf>2</inf>induction by LL-37

Periodontal disease is caused by microorganisms and host-derived inflammation involving increased cyclooxygenase-2 (COX-2) expression and prostaglandin E2(PGE2) production. We previously demonstrated that human β-defensin-3 induces COX-2 and PGE2in human gingival fibroblasts (HGFs). We, therefore, a...

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Bibliographic Details
Main Authors: Pareena Chotjumlong, Jan G. Bolscher, Kamran Nazmi, Vichai Reutrakul, Chayarop Supanchart, Worakanya Buranaphatthana, Suttichai Krisanaprakornkit
Other Authors: Academic Centre for Dentistry Amsterdam
Format: Article
Published: 2018
Subjects:
Medicine
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/32678
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/32678

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