Bivalent angiotensin II suppresses oxidative stress-induced hyper-responsiveness of angiotensin II receptor type i

• Main Authors: Titiwat Sungkaworn, Chutima Jiarpinitnun, Pongkorn Chaiyakunvat, Varanuj Chatsudthipong
• 其他作者: Mahidol University
• 格式: Article
• 出版: 2018
• 主題: Chemistry; Pharmacology, Toxicology and Pharmaceutics
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/31540

Angiotensin II receptor type I (AT1R) is a G-protein coupled receptor involved in regulation of body water-electrolyte balance and blood pressure. Oxidative stress promotes AT1R oligomerization and hyper-responsiveness to its cognate ligand Ang II. In this study, bivalent Ang II, synthesized by link...